TOKYO, March 8 (Xinhua) -- Tokyo stocks closed lower Wednesday as a weak lead overnight from Wall Street dampened investor sentiment, while comments made by U.S. President Donald Trump about pharmaceuticals saw drug-related issues come under pressure.
The 225-issue Nikkei Stock Average dropped 90.12 points, or 0.47 percent, from Tuesday to end the day at 19,254.03, marking its lowest close since Feb. 28.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 4.79 points, or 0.31 percent, to finish the day at 1,550.25.
Notable decliners by the close of play comprised led by iron and steel, securities and pharmaceutical issues and declining issues outpaced advancing issues by 1,073 to 771, on the First Section.
Trading volume totaled 1,626.03 million shares on the main section on Wednesday, up from Tuesday's volume of 1,575.96 million shares.
The day's turnover on Wednesday was 2,014.4 billion yen (17.71 billion U.S. dollars).