An ambulance departs the Tree of Life synagogue following shooting at the synagogue in Pittsburgh, Pennsylvania, U.S., October 27, 2018. (Xinhua/Reuters)

WASHINGTON, Oct. 27 (Xinhua) -- A shooting at a synagogue in Pittsburgh, U.S. state of Pennsylvania, on Saturday morning resulted in "multiple fatalities and six injuries," local authorities said.

Four of those injured were police officers, three of whom were shot, at the Tree of Life Congregation in Pittsburgh's Squirrel Hill neighborhood, according to a tweet by the Pittsburgh Public Safety Department.

Local CBS affiliate KDKA reported that eight people have been killed.

The University of Pittsburgh Medical Center system said multiple victims from the shooting are being treated.

Police said the gunman, a heavy-set white male with a beard, surrendered and is in custody.

Multiple news outlets identified the shooter as Robert Bowers, a 46-year-old man from Pittsburgh. His social media posts were reportedly rife with anti-Semitic content.

Police sources told KDKA that the gunman opened fire while yelling "All Jews must die."

The shooting will be prosecuted as a hate crime and the FBI will be leading the investigation, City of Pittsburgh Public Safety Director Wendell Hissrich told reporters.

The synagogue is located at the intersection of Wilkins and Shady avenues. The neighborhood of Squirrel Hill, about 10 minutes of drive from downtown Pittsburgh, is the hub of the city's Jewish community.

The synagogue offers members a "traditional Conservative service with a modern sense of family" and shabbat service on 9:45 a.m. Saturdays, according to the Tree of Life's website.

U.S. President Donald Trump called the shooting "devastating", as he spoke to reporters at Andrews Air Force Base in state of Maryland before traveling to Indianapolis, state of Indiana, for an event.

"It's a 'terrible thing what's going on with hate in our country," he said.

Israeli Prime Minister Benjamin Netanyahu said he was heartbroken, describing the attack at the Pittsburgh synagogue as "horrendous anti-Semitic brutality."