Cholesterol byproduct boosts spread of breast cancer

Source: Xinhua| 2017-10-13 03:03:13|Editor: Zhou Xin
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CHICAGO, Oct. 12 (Xinhua) -- A study by the University of Illinois (UI) researchers found that a byproduct of cholesterol metabolism acts on specific immune cells so that they facilitate the cancer's spread instead of stopping it.

The cholesterol byproduct is a molecule called 27HC.

UI researchers fed mice with breast cancer tumors a diet high in cholesterol, and confirmed that high levels of cholesterol increased tumor growth and metastasis, and that mice treated with cholesterol-lowering drugs called statins had less metastasis.

Researchers further to inhibit the enzyme that makes 27HC during cholesterol metabolism.

"By inhibiting the enzyme that makes 27HC, we found a suppressor effect on breast cancer metastasis. This suggests that a drug treatment targeting this enzyme could be an effective therapeutic," said Amy Baek, a postdoctoral researcher at UI and the first author of the paper.

The researchers also saw unusual activity among specific immune cells, certain types of neutrophils and T-cells, at metastatic sites high in 27HC.

Normally human body's immune system has the capacity to attack cancer. But researchers found that 27HC works on immune cells to fool them into thinking the cancer is fine. It's hijacking the immune system to help the cancer spread.

As 27HC acts through the immune system, and not on the breast cancer itself, the researchers believe their findings have broad applicability for solid tumors. They performed experiments looking at colon cancer, lung cancer, melanoma and pancreatic cancer, and found that 27HC increased metastasis for all the tumor types. This suggests that a treatment targeting 27HC could be effective across multiple cancer types.

The researchers are working to further understand the pathway by which 27HC affects the immune cells.

"Breast cancer impacts roughly 1 in 8 women. We've developed fairly good strategies for the initial treatment of the disease, but many women will experience metastatic breast cancer, when the breast cancer has spread to other organs, and at that point we really don't have effective therapies," said Erik Nelson, a UI professor of molecular and integrative physiology who led the study.

"We hope to develop small-molecule drugs to inhibit 27HC," Nelson said.

The study has been published in the journal Nature Communications.