Drug promises ease for progressive multiple sclerosis: study

Source: Xinhua| 2018-10-14 00:22:46|Editor: yan
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CHICAGO, Oct. 13 (Xinhua) -- An oral therapy called ibudilast significantly reduced the rate of brain tissue loss in patients with progressive multiple sclerosis (MS), according to the results of a recent phase II trial conducted by researchers at Northwestern University (NU).

Previous research had suggested that ibudilast, an oral therapy used in Asia to treat asthma and post-stroke vertigo, may provide a neuroprotective benefit in patients with progressive MS.

In the current trial, the researchers evaluated the safety and efficacy of ibudilast in 255 patients with primary or secondary progressive multiple sclerosis. Half were randomized to receive ibudilast, while the other half received a placebo.

The researchers found that over nearly two years, ibudilast reduced the rate of brain atrophy in patients taking the active drug by 48 percent compared to those taking a placebo.

"While many treatments have been developed for relapsing forms of multiple sclerosis, progressive MS has proved more difficult to treat. If this medicine proves effective in further studies, it would be an important addition to our current therapies," said Bruce Cohen, chief of Multiple Sclerosis and Neuroimmunology in the Ken and Ruth Davee Department of Neurology at NU.

"Higher rates of brain tissue loss have been linked to an increased risk of more severe symptoms later on," Cohen explained. "These results make this medication an attractive candidate for a larger study to find out if it will be effective in reducing the risk of worsening symptoms of the disease."

Gastrointestinal symptoms were found to be the most common side effects of ibudilast, and the drug was also associated with higher rates of headache and depression.

The findings have been published in the New England Journal of Medicine.